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Genetic Toxicology & Photosafety Industrial Placement

Placement at GSK

Genetic Toxicology & Photosafety Industrial Placement

Placement at GSK

  • LocationWatford, UK
  • Position levelPlacement
  • Job period iconFull-time employment
  • Application deadline iconApply by 16 Dec, 2018
  • Application deadline iconPosted on 06 Nov, 2018
  • Start date iconStart date:
  • Visa iconVisa Sponsor
  • CompetitiveCompetitive

What does a Genetic Toxicology & Photosafety Industrial Placement have to offer?

There is overwhelming evidence that inherited mutational changes in humans are responsible for genetically determined diseases and congenital (heritable) malformations. In addition, the accumulation of somatic cell mutations is known to be implicated in cancer, and to some extent in other multi-factorial diseases. As novel drugs may represent a potential source of damage to DNA, appropriate testing is required to minimise the risk of genotoxicity for both ethical and legislative reasons. The discipline of genetic toxicology as applied to drug development exists to achieve this aim.

The minimum genotoxicity package consists of (a) an in vitro bacterial assay for gene mutation, (b) an in vitro mammalian cell assay for gene mutation and/or cytogenetic damage, and (c) an in vivo mammalian assay for cytogenetic damage. A negative result in all three assays is usually sufficient to provide evidence for a lack of genotoxic potential. Compounds in early development maybe tested in “cut down” versions of the standard assays to assist with candidate selection and development prioritisation.

Additional testing may be required for substances with structural chemical alerts, or when there is evidence of the carcinogenicity of structurally similar compounds. More testing is also needed if one or more of the standard or candidate selection assays produces a positive result. Such investigations are often used to provide mechanism based risk assessments e.g. for compounds that induce chromosome loss (aneugens) a threshold based argument may be used for risk assessment based on safe margins of exposure in the patient population. As such, the genetic toxicology unit undertakes a variety of research projects to evaluate innovative technologies or to investigate issues associated with the risk assessment of genetic damage.

Students undertaking a placement in genetic toxicology will perform investigative studies associated with the work of the dept. This will undertake the form of a research project to consist of literature review and the establishment of expertise in one or more of the following technologies: flow cytometry, bacterial and mammalian cell/tissue culture, microscopy and image analysis. Following appropriate training, students will be expected to conduct independent research and collate and analyse experimental data, write reports/summaries and a dissertation at the end of year. They will also be expected to present the results of their work at the annual students review and external meetings, if appropriate.

In addition, students will develop knowledge of the drug development process and the role of safety assessment and genetic toxicology; be involved in general laboratory management duties throughout the year to gain valuable experience in the daily workings of an industrial genetic toxicology lab to support the screening of potential new medicines; develop scientific, IT and other core skills..

Degree Requirements:

  • Must be on track for a 2.1 (or above) in your undergraduate degree.
  • You will have completed a minimum of 2 years of a relevant biological sciences undergraduate degree, but will not have graduated at the start of your placement.
  • Students are expected to be able to demonstrate sound scientific ability and should be achieving grades equivalent to 2:1 or above.
  • Applications will be accepted from a wide range of biomedical disciplines including (but not exhaustive); pharmacology, immunology, biomedical, biochemistry, biology, genetics and related courses.
  • Ideally you will be currently studying for a degree in Genetics including a module on Genetic Toxicology.

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